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5-HYDROXYTRYPTAMINE UPTAKE INHIBITORS
Descriptors Found:
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DeCS
Descriptor
English
:
Serotonin Uptake Inhibitors
Descriptor
Spanish
:
Inhibidores de Captación de Serotonina
Descriptor
Portuguese
:
Inibidores de Captação de Serotonina
Synonyms
English
:
Serotonin Reuptake Inhibitors
5-Hydroxytryptamine Uptake Inhibitors
5-HT Uptake Inhibitors
Tree Number:
D27.505.519.625.600.850
D27.505.519.625.850.900
D27.505.696.577.600.850
D27.505.696.577.850.900
Definition
English
:
Compounds that specifically inhibit the reuptake of
serotonin
in the
brain
. This increases the
serotonin
concentration in the synaptic cleft which then activates
serotonin
receptors to a greater extent. These agents have been used in treatment of
depression
,
panic disorder
, obsessive-compulsive
behavior
, and
alcoholism
, as
analgesics
, and to treat
obesity
and
bulimia
. Many of the
ADRENERGIC UPTAKE INHIBITORS
also inhibit
serotonin
uptake; they are not included here.
Indexing Annotation
English
:
GEN or unspecified; prefer specifics; do not confuse with
SEROTONIN ANTAGONISTS
; DF:
SEROTONIN
UPTAKE INHIB
See Related
English
:
Adrenergic Uptake Inhibitors
Antidepressive Agents, Second-Generation
History Note
English
:
93
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
30515
Unique Identifier:
D017367
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS